Vyvanse Detection Time
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Vyvanse Detection Time – How Long Does Vyvanse Stay In Your System?

Isaac Alexis, M.D., AAMA, AMP-BC

Medically reviewed by

Isaac Alexis, M.D., AAMA, AMP-BC

February 11, 2019

Vyvanse is a stimulant medication that can be detectable in the body for a few days after the last dose. The time frame for drug detection can vary based on certain factors, including body size, drug dosage, and the testing method used.

When taken as prescribed, Vyvanse may remain detectable in a person’s system for up to three days. This average detection time applies to the detection of Vyvanse in urine, and can vary when being tested through other methods.

Personal factors can influence how long Vyvanse remains in the body, including how the drug is used. Vyvanse is a drug with a high risk for abuse, and this can impact how long Vyvanse remains detectable in the body.

Vyvanse (Lisdexamfetamine Dimesylate) Detection Time

The half-life of a drug is the time it takes for half of the drug to be eliminated from the body. The half-life of Vyvanse is about 12 hours.

It can take up to 5.5 half-lives (or 60 hours for Vyvanse) for the drug to be fully processed and removed from the body. However, different testing methods can vary in their effectiveness, and may vary in how long they may detect the drug.

The types of testing methods for Vyvanse detection are:

  • Blood And Saliva: Blood and saliva tests may show traces of Vyvanse within eight to 24 hours after last use.
  • Urine: Vyvanse may be detectable in the urine for two to three days.
  • Hair: Vyvanse may be detected in a person’s hair follicles for about a month.

Urine tests are one of the most common methods for drug detection as a non-invasive, quick, and effective means of testing.

Saliva tests are also non-invasive, but have a shorter detection window and may not always provide accurate results. Blood tests have the shortest window for detecting Vyvanse in the body, but are more invasive and potentially expensive.

Hair tests are a method that involves collecting and studying a person’s hair follicles for traces of certain drugs. Hair tests have the longest window for detecting drugs in the system, and may detect traces of most drugs in the hair for one to three months.

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How Is Vyvanse Metabolized?

Drug metabolism is the process of the body breaking down the drug into substances known as metabolites. The active ingredient in Vyvanse, lisdexamfetamine, when taken is metabolized into dextroamphetamine. This is an amphetamine-like substance that can be detected in drug tests. It is also responsible for the drug’s effects.

While lisdexamfetamine may only be detectable in the body for a few hours, dextroamphetamine can remain in the body for two to three days.

Factors That Influence How Long Vyvanse Stays In Your System

The detection time of Vyvanse can vary based on several factors, including whether or not a person is taking the drug as prescribed.

Abusing the drug by taking it in larger quantities or more frequently than directed can affect how quickly your body is able to remove the drug from your system.

In addition, there are several personal factors that can affect how long it takes for Vyvanse to be metabolized.

The factors that can influence how long Vyvanse stays in your system are:

  • dose
  • body mass index (BMI)
  • age
  • health


The amount of Vyvanse you take, and how often, can impact how long the drug may remain detectable in your body. Larger doses of Vyvanse may take longer to be processed and removed.

Abuse of the drug, which can include large or too-frequent doses, may result in longer detection times, as well as withdrawal symptoms.

Body Mass Index (BMI)

A person’s body mass index (BMI), or a ratio of height to weight, can affect how long a drug remains in their system. When taking a dosage proportional to body mass, people of a higher weight may process drugs more slowly.

Slower metabolic function in people of higher or lower weights may cause longer detection times. On the other hand, a fast metabolism may speed up the removal of the drug from the body.


Human metabolism tends to slow with age, which can affect how long it takes for your body to metabolize drugs. Older individuals may then metabolize drugs more slowly and experience longer detection times.


Those with better health tend to metabolize substances quicker. Lifestyle factors such as a balanced diet and regular exercise can play a role in physical health and metabolism.

Certain health conditions can also affect metabolic rate and potentially slow the process of drug elimination.

Vyvanse Abuse And Addiction

When taking Vyvanse as prescribed by a doctor, it can be a safe and effective treatment for its intended use.

However, Vyvanse, like other stimulants, has a high risk of abuse. Taking the medication in higher doses than prescribed or for off-label uses can increase the risk of developing a tolerance to the drug. Those who develop a tolerance may take more of the drug to feel the same effects they experienced previously. This can lead to physical dependency — or, addiction.

Amphetamines like Vyvanse may also be abused for effects such as improved concentration, low appetite, and weight loss. Although these side effects can occur with prescribed use of the drug, they may be more intense or prominent with stimulant abuse.

Signs Of Vyvanse Abuse

Abusing drugs like Vyvanse can put a person at risk for dangers to their physical and mental wellbeing. It is important to be able to recognize the signs of Vyvanse abuse so that a person can get the help they need.

Signs of Vyvanse abuse include:

  • rapid or unexplained weight loss
  • fatigue
  • sleeping problems
  • depression
  • bouts of anger or paranoia
  • psychosis
  • snorting or injecting the drug

Abuse of the drug can also lead to long-term problems such as addiction. Drug addiction is a mental disease that can harm both the mind and the body, and can be difficult to overcome alone.

Those who have become addicted to Vyvanse may need professional treatment in order to overcome their substance abuse.

Treatment For Vyvanse Abuse

Individuals who have become addicted to Vyvanse will first need to enter a detox program to safely withdraw from the drug. After detoxing, treatment within a residential rehab facility may also be needed to address the mental and emotional aspects of the addiction.

Residential rehab programs can offer comprehensive treatment capable of addressing all aspects of a person’s substance abuse. Behavioral therapies such as cognitive behavioral therapy (CBT) are often used as an effective treatment option for stimulant addiction.

Personal factors such as a co-occurring mental disorder may also be considered in constructing a personalized treatment plan that will best meet your needs.

To learn more about Vyvanse abuse and available treatment options, contact one of our specialists today.

National Institutes of Health: MedlinePlus - Lisdexamfetamine, Substance Use - Amphetamines

National Institute on Drug Abuse - DrugFacts: Prescription Stimulants

Food and Drug Administration - Vyvanse

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